Sep 01, 2019
September 2019: CryoCrate LLC Won a NIH SBIR Phase II Grant to Produce, Test and Commercialize “INSTAvitria®”, a Novel Tissue Cryopreservation Device System.
CryoCrate collaborating with Dr. Peter Koulen, the director of UMKC Vision Research Center, won a NIH SBIR phase II award. The goal of this project is to develop a new platform technology and produce a universal device system for efficient cryopreservation of human donor and bioartificial tissues. Continuing our Phase I studies, we will finalize a device product as a direct vitrification system, INSTAvitria®, which achieves high efficiency in cryopreservation of these tissues without using any cryoprotectant. The success of the project will bring significant impact on tissue transportation (e.g. corneal transplantation) and tissue engineering technologies (e.g. artificial retinal tissue production).
Aug 02, 2018
August 2018: Dr. Han and His Group Won a Coulter Translational Research Partnership Award for Rat Heart Cryopreservation.
Dr. Han as the clinical PI collaborating with Dalton Cardiovascular Research Center and College of Engineering at University of Missouri won a Coulter Translational Research Partnership award to develop a novel organ freezing medium that enable one-week storage of organs at -20°C (i.e. in regular lab freezer), using rat hearts as the model. If this technology can be translated to human hearts, it will potentially solve the severe management issues caused by the relatively short shelf-life of donor hearts (4-6 hour in hypothermia) and saves thousands of lives in USA alone each year.
Aug 01, 2018
August 2018: CryoCrate LLC Won a NIH SBIR Phase I Award for a Novel Stem Cell Cryopreservation Method.
CryoCrate collaborating with the Dean of the College of Engineering at University of Missouri at Columbia won a NIH SBIR phase I award. A novel system will be developed to enable significantly higher efficiency (over 90% post-thaw viability) in existing stem cell cryopreservation method, removes the need for animal origin products (e.g. serum, albumin, etc) and minimizes the cryoprotectant concentration. The method also prevents issues generated by donor variation that impairs various regenerative medicine applications.
Jul 02, 2018
July 2018: CryoCrate LLC Won a USDA NIFA SBIR Phase I Award for Cryopreservation of Intact Porcine Embryos.
CryoCrate collaborating with National Swine Research and Resource Center at University of Missouri at Columbia won a USDA NIFA SBIR phase I award. The novel method will solve the long existing issues in cryopreservation of lipid rich porcine embryos, and remove the need of delipidation for pig embryo handling and processing for any storage protocol. The technology will potentially open a new market for long-term storage of pig embryos, which has never existed but can reach the same value as that for bovine embryos: each year, hundreds of thousands of bovine embryos are cryopreserved and distributed. It can potentially bring significant impact on embryo transfer and breeding improvement market for pigs.
Apr 03, 2017
CryoCrate received a convertible note from Centennial Investors, a local investor group at Columbia MO. The note will be used to establish production line of C80EZ®, hire a business team, establish an online sales platform and cover other business expenses.
Jun 01, 2016
Dr. Han collaborating with MU Research Reactor and won a MU Fast-track award for studies and practices in building GMP production of cryopreservation media. The award covered various tests for potential 510(K) clearance for a novel cryopreservation medium, including pH values, sterility, osmolarity, endotoxin and stability.
Nov 01, 2015
November 2015: Dr. Han Won a Coulter Translation Research Partnership Award for Corneal Cryopreservation Technology Development.
Dr. Han collaborating with the School of Medicine at University of Missouri at Columbia won a Coulter Translation Research Partnership Award. The project initiated the R&D activities that resulted in the invention of the IcyEye® kit (see Technology for details).
Jul 01, 2015
July 2015: CryoCrate Received its First NIH SBIR Phase I Award for Developing Ultra-fast Cooling Technology for Tissue Cryopreservation.
CryoCrate collaborating with the UMKC Vision Research Center won its first NIH SBIR phase I award. The project initiated the R&D activities that resulted in the invention of the INSTAvitria® (see Technology for details) for tissue cryopreservation.
Aug 01, 2013
Dr. Han collaborating with the Dr. Michael Roberts, a member of National Academic of Sciences, to develop a novel cryopreservation media and procedure to enable long-term storage and safe shipment of both epiblast and naïve type stem cells at temperatures near -80°C (e.g. in a deep freezer or dry ice box). The project initiated the R&D activities that resulted in the invention of C80EZ® media (see Technology for details).